Evaluation of efficacy, effectiveness and safety of Subolesin anti-tick vaccine in Ugandan multi-site field trial.

Vaccines are the most effective and sustainable intervention to control ticks and tick-borne diseases (TBD). Using a personalized vaccine design based on regional tick genotypes, a Rhipicephalus appendiculatus Subolesin protective antigen was used in a field trial evaluating tick vaccine efficacy, e...

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Autores: Kabi , F, Contreras Rojo, Marinela, Semakula , J, Muñoz Hernández, Clara, Mugerwa , Swidiq, Kasaija , Paul Davies, Kirunda , H, de la Fuente , Gabriela, Fernández Melgar, Rubén, Matovu , M, Kyakuwa , I, Dhikusooka , M, Nsereko , G, Boma , P, Bugeza , J, Moses , M, Namukasa , A, Obonyo , P, Rutaisire , Justus, Sánchez Sánchez, Marta, Mateo Soria, Rafael, García Fernández de Mera, María Isabel, Gortázar Schmidt, Ramón Christian, Fuente García, José de Jesús de la
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universidad de Castilla-La Mancha
Repositorio:RUIdeRA. Repositorio Institucional de la UCLM
OAI Identifier:oai:ruidera.uclm.es:10578/40898
Acceso en línea:https://www.nature.com/articles/s41541-024-00966-1
https://hdl.handle.net/10578/40898
Access Level:acceso abierto
Palabra clave:Subolesin anti-tick vaccine
Ugandan
Descripción
Sumario:Vaccines are the most effective and sustainable intervention to control ticks and tick-borne diseases (TBD). Using a personalized vaccine design based on regional tick genotypes, a Rhipicephalus appendiculatus Subolesin protective antigen was used in a field trial evaluating tick vaccine efficacy, effectiveness, and safety in cattle infested with multiple tick species in different Ugandan agro-ecological zones. Vaccination with SUB was safe with a protective capacity against anemia and infection, and reduced the number of infested cattle, tick fitness (feeding and reproduction) with vaccine effectiveness against multiple tick species between 93.2% at 167-196 days post-vaccination (dpv) and 61.4% at 251-327 dpv. Total integrated vaccine efficacy/effectiveness was estimated as 98.8%. The Subolesin-based vaccine is protective against multiple cattle tick infestations under field conditions in Uganda. These results support registration and commercialization of the vaccine to reduce tick populations and associated risks for human and animal TBD and chemical acaracides in Uganda.

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