Depth sensitivity of frequency domain optical measurements in diffusive media

The depth sensitivity functions for AC amplitude, phase (PH) and DC intensity signals have been obtained in the frequency domain (where the source amplitude is modulated at radio-frequencies) by making use of analytical solutions of the photon diffusion equation in an infinite slab geometry. Further...

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Autores: BINZONI, TIZIANO, SASSAROLI, ANGELO, TORRICELLI, ALESSANDRO, SPINELLI, LORENZO, FARINA, ANDREA, DURDURAN, TURGUT, CAVALIER, STEFANO, PIFFERI, ANTONIO, MARTELLI, FABRIZIO
Tipo de documento: artigo
Data de publicação:2017
País:España
Recursos:Universitat Politècnica de Catalunya (UPC)
Repositório:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglês
OAI Identifier:oai:upcommons.upc.edu:2117/104599
Acesso em linha:https://hdl.handle.net/2117/104599
Access Level:Acceso aberto
Palavra-chave:photons
optical measurements
Fotons
Àrees temàtiques de la UPC::Física
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oai_identifier_str oai:upcommons.upc.edu:2117/104599
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spelling Depth sensitivity of frequency domain optical measurements in diffusive media BINZONI, TIZIANO SASSAROLI, ANGELO TORRICELLI, ALESSANDRO SPINELLI, LORENZO FARINA, ANDREA DURDURAN, TURGUT CAVALIER, STEFANO PIFFERI, ANTONIO MARTELLI, FABRIZIO photons optical measurements Fotons Àrees temàtiques de la UPC::Física The depth sensitivity functions for AC amplitude, phase (PH) and DC intensity signals have been obtained in the frequency domain (where the source amplitude is modulated at radio-frequencies) by making use of analytical solutions of the photon diffusion equation in an infinite slab geometry. Furthermore, solutions for the relative contrast of AC, PH and DC signals when a totally absorbing plane is placed at a fixed depth of the slab have also been obtained. The solutions have been validated by comparisons with gold standard Monte Carlo simulations. The obtained results show that the AC signal, for modulation frequencies < 200 MHz, has a depth sensitivity with similar characteristics to that of the continuous-wave (CW) domain (source modulation frequency of zero). Thus, the depth probed by such a signal can be estimated by using the formula of penetration depth for the CW domain (Sci. Rep. 6, 27057 (2016)). However, the PH signal has a different behavior compared to the CW domain, showing a larger depth sensitivity at shallow depths and a less steep relative contrast as a function of depth. These results mark a clear difference in term of depth sensitivity between AC and PH signals, and highlight the complexity of the estimation of the actual depth probed in tissue spectroscopy. OSA https://hdl.handle.net/2117/104599 28663921
title Depth sensitivity of frequency domain optical measurements in diffusive media
spellingShingle Depth sensitivity of frequency domain optical measurements in diffusive media
BINZONI, TIZIANO
photons
optical measurements
Fotons
Àrees temàtiques de la UPC::Física
title_short Depth sensitivity of frequency domain optical measurements in diffusive media
title_full Depth sensitivity of frequency domain optical measurements in diffusive media
title_fullStr Depth sensitivity of frequency domain optical measurements in diffusive media
title_full_unstemmed Depth sensitivity of frequency domain optical measurements in diffusive media
title_sort Depth sensitivity of frequency domain optical measurements in diffusive media
author BINZONI, TIZIANO
author_facet BINZONI, TIZIANO
SASSAROLI, ANGELO
TORRICELLI, ALESSANDRO
SPINELLI, LORENZO
FARINA, ANDREA
DURDURAN, TURGUT
CAVALIER, STEFANO
PIFFERI, ANTONIO
MARTELLI, FABRIZIO
author_role author
author2 SASSAROLI, ANGELO
TORRICELLI, ALESSANDRO
SPINELLI, LORENZO
FARINA, ANDREA
DURDURAN, TURGUT
CAVALIER, STEFANO
PIFFERI, ANTONIO
MARTELLI, FABRIZIO
author2_role author
author
author
author
author
author
author
author
topic photons
optical measurements
Fotons
Àrees temàtiques de la UPC::Física
topic_facet photons
optical measurements
Fotons
Àrees temàtiques de la UPC::Física
description The depth sensitivity functions for AC amplitude, phase (PH) and DC intensity signals have been obtained in the frequency domain (where the source amplitude is modulated at radio-frequencies) by making use of analytical solutions of the photon diffusion equation in an infinite slab geometry. Furthermore, solutions for the relative contrast of AC, PH and DC signals when a totally absorbing plane is placed at a fixed depth of the slab have also been obtained. The solutions have been validated by comparisons with gold standard Monte Carlo simulations. The obtained results show that the AC signal, for modulation frequencies < 200 MHz, has a depth sensitivity with similar characteristics to that of the continuous-wave (CW) domain (source modulation frequency of zero). Thus, the depth probed by such a signal can be estimated by using the formula of penetration depth for the CW domain (Sci. Rep. 6, 27057 (2016)). However, the PH signal has a different behavior compared to the CW domain, showing a larger depth sensitivity at shallow depths and a less steep relative contrast as a function of depth. These results mark a clear difference in term of depth sensitivity between AC and PH signals, and highlight the complexity of the estimation of the actual depth probed in tissue spectroscopy.
publishDate 2017
format article
url https://hdl.handle.net/2117/104599
identifier_str_mv 28663921
language eng
eu_rights_str_mv openAccess
publisher OSA
institution Universitat Politècnica de Catalunya (UPC)
collection UPCommons. Portal del coneixement obert de la UPC
reponame_str UPCommons. Portal del coneixement obert de la UPC
instname_str Universitat Politècnica de Catalunya (UPC)
_version_ 1878440798759944192
publishDateSort 2017
author_browse BINZONI, TIZIANO
CAVALIER, STEFANO
DURDURAN, TURGUT
FARINA, ANDREA
MARTELLI, FABRIZIO
PIFFERI, ANTONIO
SASSAROLI, ANGELO
SPINELLI, LORENZO
TORRICELLI, ALESSANDRO
publisherStr OSA
score 6,924472

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