Urinary metabolic signatures reflect cardiovascular risk in the young, middle-aged, and elderly populations
The predictive value of traditional cardiovascular risk estimators is limited, and young and elderly populations are particularly underrepresented. We aimed to investigate the urine metabolome and its association with cardiovascular risk to identify novel markers that might complement current estima...
| Autores: | , , , , , , , , , , |
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| Formato: | artículo |
| Fecha de publicación: | 2020 |
| País: | España |
| Recursos: | Universidad Europea (UEM) |
| Repositorio: | ABACUS. Repositorio de Producción Científica |
| Idioma: | inglés |
| OAI Identifier: | oai:abacus.universidadeuropea.com:11268/9619 |
| Acesso em linha: | http://hdl.handle.net/11268/9619 |
| Access Level: | acceso abierto |
| Palavra-chave: | Metabolismo Ancianos Aparato urinario Anciano Sistema cardiovascular |
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oai:abacus.universidadeuropea.com:11268/9619 |
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Urinary metabolic signatures reflect cardiovascular risk in the young, middle-aged, and elderly populations Martínez, Paula J. Agudiez, Marta Molero, Dolores Martín Lorenzo, Marta Baldán Martín, Montserrat Santiago Hernández, Aranzazu García Segura, Juan Manuel Madruga, Felipe Cabrera, Martha Ruilope Urioste, Luis Miguel Et al. Metabolismo Ancianos Aparato urinario Anciano Sistema cardiovascular The predictive value of traditional cardiovascular risk estimators is limited, and young and elderly populations are particularly underrepresented. We aimed to investigate the urine metabolome and its association with cardiovascular risk to identify novel markers that might complement current estimators based on age. Urine samples were collected from 234 subjects categorized into three age-grouped cohorts: 30–50 years (cohort I, young), 50–70 years (cohort II, middle-aged), and > 70 years (cohort III, elderly). Each cohort was further classified into three groups: (a) control, (b) individuals with cardiovascular risk factors, and (c) those who had a previous cardiovascular event. Novel urinary metabolites linked to cardiovascular risk were identified by nuclear magnetic resonance in cohort I and then evaluated by target mass spectrometry quantification in all cohorts. A previously identified metabolic fingerprint associated with atherosclerosis was also analyzed and its potential risk estimation investigated in the three aged cohorts. Three different metabolic signatures were identified according to age: 2-hydroxybutyrate, gamma-aminobutyric acid, hypoxanthine, guanidoacetate, oxaloacetate, and serine in young adults; citrate, cyclohexanol, glutamine, lysine, pantothenate, pipecolate, threonine, and tyramine shared by middle-aged and elderly adults; and trimethylamine N-oxide and glucuronate associated with cardiovascular risk in all three cohorts. The urinary metabolome contains a metabolic signature of cardiovascular risk that differs across age groups. These signatures might serve to complement existing algorithms and improve the accuracy of cardiovascular risk prediction for personalized prevention. http://hdl.handle.net/11268/9619 |
| title |
Urinary metabolic signatures reflect cardiovascular risk in the young, middle-aged, and elderly populations |
| spellingShingle |
Urinary metabolic signatures reflect cardiovascular risk in the young, middle-aged, and elderly populations Martínez, Paula J. Metabolismo Ancianos Aparato urinario Anciano Sistema cardiovascular |
| title_short |
Urinary metabolic signatures reflect cardiovascular risk in the young, middle-aged, and elderly populations |
| title_full |
Urinary metabolic signatures reflect cardiovascular risk in the young, middle-aged, and elderly populations |
| title_fullStr |
Urinary metabolic signatures reflect cardiovascular risk in the young, middle-aged, and elderly populations |
| title_full_unstemmed |
Urinary metabolic signatures reflect cardiovascular risk in the young, middle-aged, and elderly populations |
| title_sort |
Urinary metabolic signatures reflect cardiovascular risk in the young, middle-aged, and elderly populations |
| author |
Martínez, Paula J. |
| author_facet |
Martínez, Paula J. Agudiez, Marta Molero, Dolores Martín Lorenzo, Marta Baldán Martín, Montserrat Santiago Hernández, Aranzazu García Segura, Juan Manuel Madruga, Felipe Cabrera, Martha Ruilope Urioste, Luis Miguel Et al. |
| author_role |
author |
| author2 |
Agudiez, Marta Molero, Dolores Martín Lorenzo, Marta Baldán Martín, Montserrat Santiago Hernández, Aranzazu García Segura, Juan Manuel Madruga, Felipe Cabrera, Martha Ruilope Urioste, Luis Miguel Et al. |
| author2_role |
author author author author author author author author author author |
| topic |
Metabolismo Ancianos Aparato urinario Anciano Sistema cardiovascular |
| topic_facet |
Metabolismo Ancianos Aparato urinario Anciano Sistema cardiovascular |
| description |
The predictive value of traditional cardiovascular risk estimators is limited, and young and elderly populations are particularly underrepresented. We aimed to investigate the urine metabolome and its association with cardiovascular risk to identify novel markers that might complement current estimators based on age. Urine samples were collected from 234 subjects categorized into three age-grouped cohorts: 30–50 years (cohort I, young), 50–70 years (cohort II, middle-aged), and > 70 years (cohort III, elderly). Each cohort was further classified into three groups: (a) control, (b) individuals with cardiovascular risk factors, and (c) those who had a previous cardiovascular event. Novel urinary metabolites linked to cardiovascular risk were identified by nuclear magnetic resonance in cohort I and then evaluated by target mass spectrometry quantification in all cohorts. A previously identified metabolic fingerprint associated with atherosclerosis was also analyzed and its potential risk estimation investigated in the three aged cohorts. Three different metabolic signatures were identified according to age: 2-hydroxybutyrate, gamma-aminobutyric acid, hypoxanthine, guanidoacetate, oxaloacetate, and serine in young adults; citrate, cyclohexanol, glutamine, lysine, pantothenate, pipecolate, threonine, and tyramine shared by middle-aged and elderly adults; and trimethylamine N-oxide and glucuronate associated with cardiovascular risk in all three cohorts. The urinary metabolome contains a metabolic signature of cardiovascular risk that differs across age groups. These signatures might serve to complement existing algorithms and improve the accuracy of cardiovascular risk prediction for personalized prevention. |
| publishDate |
2020 |
| format |
article |
| url |
http://hdl.handle.net/11268/9619 |
| language |
eng |
| eu_rights_str_mv |
openAccess |
| institution |
Universidad Europea (UEM) |
| collection |
ABACUS. Repositorio de Producción Científica |
| reponame_str |
ABACUS. Repositorio de Producción Científica |
| instname_str |
Universidad Europea (UEM) |
| _version_ |
1878441066176184320 |
| publishDateSort |
2020 |
| author_browse |
Agudiez, Marta Baldán Martín, Montserrat Cabrera, Martha Et al. García Segura, Juan Manuel Madruga, Felipe Martín Lorenzo, Marta Martínez, Paula J. Molero, Dolores Ruilope Urioste, Luis Miguel Santiago Hernández, Aranzazu |
| score |
6,924472 |