Oxidative stress, the blood–brain barrier and neurodegenerative diseases: The critical beneficial role of dietary antioxidants
In recent years, growing awareness of the role of oxidative stress in brain health has prompted antioxidants, especially dietary antioxidants, to receive growing attention as possible treatments strategies for patients with neurodegenerative diseases (NDs). The most widely studied dietary antioxidan...
| Autores: | , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Universidad Complutense de Madrid (UCM) |
| Repositorio: | Docta Complutense |
| Idioma: | inglés |
| OAI Identifier: | oai:docta.ucm.es:20.500.14352/104322 |
| Acceso en línea: | https://hdl.handle.net/20.500.14352/104322 |
| Access Level: | acceso abierto |
| Palabra clave: | 615.1 Dietary antioxidant supplements Oxidative stress Blood–brain barrier Neurodegenerative diseases Vitamins Carotenoids Flavonoids Polyphenols Farmacología (Farmacia) 3109.08 Farmacología |
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oai:docta.ucm.es:20.500.14352/104322 |
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ES |
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España |
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Oxidative stress, the blood–brain barrier and neurodegenerative diseases: The critical beneficial role of dietary antioxidants Feng, Jin Zheng, Youle Guo, Mingyue Ares Lombán, Irma Martínez Caballero, Marta López Torres, Bernardo Martínez Larrañaga, María Rosa Wang, Xu Anadón Navarro, Arturo Ramón Martínez Caballero, María Aranzazu 615.1 Dietary antioxidant supplements Oxidative stress Blood–brain barrier Neurodegenerative diseases Vitamins Carotenoids Flavonoids Polyphenols Farmacología (Farmacia) 3109.08 Farmacología In recent years, growing awareness of the role of oxidative stress in brain health has prompted antioxidants, especially dietary antioxidants, to receive growing attention as possible treatments strategies for patients with neurodegenerative diseases (NDs). The most widely studied dietary antioxidants include active substances such as vitamins, carotenoids, flavonoids and polyphenols. Dietary antioxidants are found in usually consumed foods such as fresh fruits, vegetables, nuts and oils and are gaining popularity due to recently growing awareness of their potential for preventive and protective agents against NDs, as well as their abundant natural sources, generally non-toxic nature, and ease of long-term consumption. This review article examines the role of oxidative stress in the development of NDs, explores the ‘two-sidedness’ of the blood–brain barrier (BBB) as a protective barrier to the nervous system and an impeding barrier to the use of antioxidants as drug medicinal products and/or dietary antioxidants supplements for prevention and therapy and reviews the BBB permeability of common dietary antioxidant suplements and their potential efficacy in the prevention and treatment of NDs. Finally, current challenges and future directions for the prevention and treatment of NDs using dietary antioxidants are discussed, and useful information on the prevention and treatment of NDs is provided. Chinese Pharmaceutical Association https://hdl.handle.net/20.500.14352/104322 |
| title |
Oxidative stress, the blood–brain barrier and neurodegenerative diseases: The critical beneficial role of dietary antioxidants |
| spellingShingle |
Oxidative stress, the blood–brain barrier and neurodegenerative diseases: The critical beneficial role of dietary antioxidants Feng, Jin 615.1 Dietary antioxidant supplements Oxidative stress Blood–brain barrier Neurodegenerative diseases Vitamins Carotenoids Flavonoids Polyphenols Farmacología (Farmacia) 3109.08 Farmacología |
| title_short |
Oxidative stress, the blood–brain barrier and neurodegenerative diseases: The critical beneficial role of dietary antioxidants |
| title_full |
Oxidative stress, the blood–brain barrier and neurodegenerative diseases: The critical beneficial role of dietary antioxidants |
| title_fullStr |
Oxidative stress, the blood–brain barrier and neurodegenerative diseases: The critical beneficial role of dietary antioxidants |
| title_full_unstemmed |
Oxidative stress, the blood–brain barrier and neurodegenerative diseases: The critical beneficial role of dietary antioxidants |
| title_sort |
Oxidative stress, the blood–brain barrier and neurodegenerative diseases: The critical beneficial role of dietary antioxidants |
| author |
Feng, Jin |
| author_facet |
Feng, Jin Zheng, Youle Guo, Mingyue Ares Lombán, Irma Martínez Caballero, Marta López Torres, Bernardo Martínez Larrañaga, María Rosa Wang, Xu Anadón Navarro, Arturo Ramón Martínez Caballero, María Aranzazu |
| author_role |
author |
| author2 |
Zheng, Youle Guo, Mingyue Ares Lombán, Irma Martínez Caballero, Marta López Torres, Bernardo Martínez Larrañaga, María Rosa Wang, Xu Anadón Navarro, Arturo Ramón Martínez Caballero, María Aranzazu |
| author2_role |
author author author author author author author author author |
| topic |
615.1 Dietary antioxidant supplements Oxidative stress Blood–brain barrier Neurodegenerative diseases Vitamins Carotenoids Flavonoids Polyphenols Farmacología (Farmacia) 3109.08 Farmacología |
| topic_facet |
615.1 Dietary antioxidant supplements Oxidative stress Blood–brain barrier Neurodegenerative diseases Vitamins Carotenoids Flavonoids Polyphenols Farmacología (Farmacia) 3109.08 Farmacología |
| description |
In recent years, growing awareness of the role of oxidative stress in brain health has prompted antioxidants, especially dietary antioxidants, to receive growing attention as possible treatments strategies for patients with neurodegenerative diseases (NDs). The most widely studied dietary antioxidants include active substances such as vitamins, carotenoids, flavonoids and polyphenols. Dietary antioxidants are found in usually consumed foods such as fresh fruits, vegetables, nuts and oils and are gaining popularity due to recently growing awareness of their potential for preventive and protective agents against NDs, as well as their abundant natural sources, generally non-toxic nature, and ease of long-term consumption. This review article examines the role of oxidative stress in the development of NDs, explores the ‘two-sidedness’ of the blood–brain barrier (BBB) as a protective barrier to the nervous system and an impeding barrier to the use of antioxidants as drug medicinal products and/or dietary antioxidants supplements for prevention and therapy and reviews the BBB permeability of common dietary antioxidant suplements and their potential efficacy in the prevention and treatment of NDs. Finally, current challenges and future directions for the prevention and treatment of NDs using dietary antioxidants are discussed, and useful information on the prevention and treatment of NDs is provided. |
| publishDate |
2023 |
| format |
article |
| url |
https://hdl.handle.net/20.500.14352/104322 |
| language |
eng |
| eu_rights_str_mv |
openAccess |
| publisher |
Chinese Pharmaceutical Association |
| institution |
Universidad Complutense de Madrid (UCM) |
| collection |
Docta Complutense |
| reponame_str |
Docta Complutense |
| instname_str |
Universidad Complutense de Madrid (UCM) |
| _version_ |
1878443254156886016 |
| publishDateSort |
2023 |
| author_browse |
Anadón Navarro, Arturo Ramón Ares Lombán, Irma Feng, Jin Guo, Mingyue López Torres, Bernardo Martínez Caballero, Marta Martínez Caballero, María Aranzazu Martínez Larrañaga, María Rosa Wang, Xu Zheng, Youle |
| publisherStr |
Chinese Pharmaceutical Association |
| score |
6,9303427 |